Results
| PMID | 16635455 |
| Gene Name | TNFRSF11B |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 132 |
| Population details | 132 (77 women were diagnosed with endometriosis, 55 women were free of the disease and served as control subjects) |
| Sex | Female |
| Associated genes | PAPPA, glycodelin, osteoprotegerin, CD163 |
| Other associated phenotypes |
Endometriosis |
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Am J Obstet Gynecol. 2006 Jul;195(1):103-8. Epub 2006 Apr 25. Bersinger, Nick A| von Roten, Stephanie| Wunder, Dorothea M| Raio, Luigi| Dreher, Ekkehard| Mueller, Michael D Endometriosis Centre, Department of Obstetrics and Gynaecology, University of Berne, Switzerland. OBJECTIVE: The purpose of this study was to evaluate whether pregnancy-associated plasma protein A, glycodelin, osteoprotegerin, and soluble CD163 are possible peritoneal fluid markers for endometriosis and to compare them with the established chemokine markers interleukin-8 and regulated on activation, normal T-cell expressed and secreted. STUDY DESIGN: Determination of the concentrations of interleukin-8, regulated on activation, normal T-cell expressed and secreted, pregnancy-associated plasma protein A, glycodelin, CD163, osteoprotegerin, and progesterone in the peritoneal fluid collected from women undergoing laparoscopy. RESULTS: From a total of 132 women, 77 women were diagnosed with endometriosis, and 55 women were free of the disease and served as control subjects. Pregnancy-associated plasma protein A and osteoprotegerin showed significantly (P < 0.05) elevated peritoneal fluid concentrations as a function of the severity of the disease, together with interleukin-8 and regulated on activation, normal T-cell expressed and secreted (P < .001). Glycodelin and CD163 did not differ between cases and control subjects. Many of these marker concentrations were intercorrelated strongly. CONCLUSION: Pregnancy-associated plasma protein A and osteoprotegerin may play a role in the inflammation process of endometriosis, but interleukin-8 and regulated on activation, normal T-cell expressed and secreted are superior peritoneal fluid markers. Mesh Terms: Adult| Ascitic Fluid/*chemistry| Chemokine CCL5/*analysis| Endometriosis/*metabolism| Female| Glycoproteins/*analysis| Humans| Interleukin-8/*analysis| Osteoprotegerin| Pregnancy-Associated Plasma Protein-A/*analysis| Receptors, Cytoplasmic and |
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